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. 2001 Sep 1;118(3):251–266. doi: 10.1085/jgp.118.3.251

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Swelling-induced activation of large-conductance single-channel currents in on-cell patches. (A) Representative current traces recorded under isotonic and hypotonic conditions on C127i (top traces) and C127/CFTR (bottom traces) cells, during application of alternating pulses from 0 to ±25 mV (protocol is shown at the top of the traces). (B) Unitary i-V relationships recorded in cell-attached patches on C127i (open circles) and C127/CFTR cells (open triangles) as well as in inside-out patches excised from C127i cells (closed circles). The SEM values are shown by vertical bars where the values exceed the symbol size.