TABLE III.
Effect of UV on BPMTS-labeled Cysteine Mutants
Voltage | Percentage reduction | Parameter | n | |
---|---|---|---|---|
mV | ||||
L1433C-BP | −140 | 6.4 ± 1.2 | peak | 5 |
0 | 19.5 ± 2.8 | peak | 4 | |
L1431C-BP | −140 | 5.8 ± 3.4 | τh | 4 |
0 | 29.7 ± 1.7 | τh | 3 | |
G1430C-BP | −140 | 14.3 ± 2.4 | peak | 4 |
0 | 20.0 ± 2.1 | peak | 4 | |
S1427C-BP | −140 | 0.1 ± 1.4 | peak | 3 |
0 | 14.1 ± 1.0 | peak | 3 |
Reductions of either peak sodium current or τh at −20 mV caused by 22 s irradiation at the indicated membrane potential.