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. 2002 Sep;120(3):337–347. doi: 10.1085/jgp.20028617

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Copyright © 2002, The Rockefeller University Press

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Figure 3. — CaM binding–deficient RyR1 mutants respond normally to both electrical stimulation and 4-cmc. (A) Representative traces for dyspedic, RyR1-, and L3624D-expressing myotubes. Arrows indicate the beginning of a train of electrical stimuli (30 s, 20-ms pulses of 8 V at 0.5 Hz). The light gray bars (60 s) define periods of 10 mM caffeine application and black bars (60 s) define periods of 500 μM 4-cmc application. (Insets) The final electrically evoked Ca²⁺ transient from each train is shown on an expanded scale (scale bars: 0.2 ΔRatio and 0.2 s shown for RyR1 applies to each inset). (B) Average peak response to 4-cmc (ΔRatio = R_4-cmc − R_baseline, *, P < 0.001) for uninjected dyspedic myotubes, RyR1-expressing myotubes, low and high caffeine–responsive L3624D-expressing myotubes, and W3620A-expressing myotubes. Number of experiments is given in parentheses above each bar.