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. 2002 Sep;120(3):337–347. doi: 10.1085/jgp.20028617

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Copyright © 2002, The Rockefeller University Press

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Figure 5. — CaM binding–deficient RyR1 mutants restore voltage-gated Ca²⁺ release (orthograde coupling) after expression in dyspedic myotubes. (A) Ca²⁺ transients elicited by 200 ms depolarization to the indicated potentials for representative RyR1- (left), L3624D- (middle), and W3620A-expressing (right) myotubes. (B) Average peak F-V relationship for RyR1-, L3624D-, and W3620A-expressing myotubes. The lines through the data represent Boltzmann fits to the average data using Eq. 3. For L3624D and W3620A, a dashed line representing the fit of the RyR1 data is also shown for comparison.