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. 2002 Sep;120(3):349–368. doi: 10.1085/jgp.20028620

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Copyright © 2002, The Rockefeller University Press

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Figure 5. — Single-compartment calculations that illustrate some of the kinetic differences between the Ca²⁺ troponin reactions of Models 1 and 2, [Ca²⁺]_R = 50 nM. (A) The top trace top shows a 5-ms pulse in [Ca²⁺] from 50 nM to 5 μM. The middle traces show the time courses of f, the fraction of the troponin regulatory sites that are occupied with Ca²⁺ (continuous trace, Model 1 troponin; dotted trace, Model 2 troponin). The bottom traces show the time derivative of the middle traces. (B) Like A for the spatially-averaged free [Ca²⁺] transient from Baylor and Hollingworth (1998). The peak amplitude and FDHM of the [Ca²⁺] transient are 18.0 μM and 5.3 ms, respectively.