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. 2002 Sep;120(3):437–446. doi: 10.1085/jgp.20028621

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Copyright © 2002, The Rockefeller University Press

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Figure 1. — Alanine scanning mutagenesis of NH₂-terminal basic residues of Kir6.2. (A) Each positive charged residue in the NH₂ terminus (bold), up to the beginning of the M1 transmembrane domain, was individually mutated to alanine. (B) Initial current (I_initial) in macropatches isolated from COSm6 cells cotransfected with mutant Kir6.2 subunits (as indicated) + SUR1 (mean ± SEM, n ≥ 3 in each case). See materials and methods for details.