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. 2002 Oct;120(4):567–579. doi: 10.1085/jgp.20028665

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Copyright © 2002, The Rockefeller University Press

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Figure 7. — The effect of HCl injection on pH_i and on V_Ca transients generated either by injection of CaCl₂ or by depolarizations to −20 mV for 10 s. The membrane potential was clamped at −60 mV except for brief depolarizations. After the first two depolarizations the CaCl₂ electrode was inserted and used to make several injections. Finally the HCl electrode was inserted and used to reduce pH_i. Downward offsets on the current trace indicate the periods during which Ca²⁺ or H⁺ and Cl⁻ ions were injected iontophoretically, and upward deflections indicate depolarizations. After the two periods when pH_i was reduced by HCl injection, recovery was assisted by superfusion of Ringer containing 5 mM added bicarbonate. The large vertical excursions of the pH and calcium traces were caused by electrical pickup by the amplifier inputs.