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. 2002 Oct;120(4):449–453. doi: 10.1085/jgp.20028658

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Copyright © 2002, The Rockefeller University Press

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Figure 1. — Model of the fourth homologous domain (D4) of the human skeletal muscle sodium channel (hNa_V1.4) with the S4 segment depicted as a rotating cylinder. Four S4 residues are shown: Arg1451 (R2), Leu1452, Ala1453, and Arg1454 (R3). The positions of the residues around the S4 segment roughly correspond to those of an α helical model. A depolarizing rotation transfers R2 and R3 from an intracellularly to an extracellularly accessible crevice, whereas Leu1452 and Ala1453 are translocated in the opposite direction.