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. 2002 Oct;120(4):449–453. doi: 10.1085/jgp.20028658

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Copyright © 2002, The Rockefeller University Press

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Figure 2. — Hypothetical model of two potassium channel subunits oriented opposite one another across the permeation pathway. The other two subunits, in front and behind, are removed for clarity. The activation gate is the convergence at the cytoplasmic ends of the S6 segments. The S4 segment, the positively charged cylinder, lies next to the “pore domain” (S5-S6). Three potential coupling sites are highlighted: (a) the S3-S4 linker that might interact with the top of the pore domain; (b) the S4-S5 linker that might interact with the tail end of the S6 segment; and (c) an interaction between the S4 segment and the pore domain within the transmembrane region.