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. 2003 Aug;122(2):225–237. doi: 10.1085/jgp.200308822

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Copyright © 2003, The Rockefeller University Press

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Figure 2. — Channel inactivation can be recovered by exposure to ATP and subsequent washout of ATP. (A) Inactivated R314A (left) and E229A (right) channels were reactivated by exposure to ATP (5 mM) and subsequent washout of ATP. (B) A nonhydrolyzable ATP analogue, AMP-PNP mimicked the reactivation effect of ATP in both R314A (left) and E229A (right) channels. (C) The reactivation effect of ATP was not observed in channels formed by E229A-Kir6.2ΔC25 alone (left), but was retained in channels formed by E229A-Kir6.2ΔC25 in the presence of SUR1 (right).