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. 2003 Aug;122(2):225–237. doi: 10.1085/jgp.200308822

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Copyright © 2003, The Rockefeller University Press

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Figure 3. — Inactivation of E229A mutant channels is reversed by PIP₂. Application of PIP₂ (10 μM) reversed inactivation and stimulated channel activity; it also decreased the ATP sensitivity of the channel, as was previously reported for WT channels (Baukrowitz et al., 1998; Shyng and Nichols, 1998).