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. 2002 Nov;120(5):663–676. doi: 10.1085/jgp.20028696

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Copyright © 2002, The Rockefeller University Press

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Figure 6. — Nonfunctional Shaker-KcsA chimeras with various distal COOH-terminal junctions and their rescue by the replacement of the S4–S5 linker. (A and B) Two distinct sequence alignments between Shaker and KcsA in S6/M2-COOH terminus. The distal junction in four chimeric constructs is indicated by the arrows. (C) Alignment of Shaker's S4–S5 linker sequence and its KcsA counterpart (the arrows indicate two alternative proximal junctions). (D–K) Current records from oocytes injected with RNA encoding four chimeras with different distal junctions as indicated. Chimeras corresponding to D-G have a proximal junction that preserves Shaker's S4–S5 linker, whereas in those corresponding to H–K the Shaker S4–S5 linker is replaced by its KcsA counterpart.