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. 2002 Nov;120(5):739–755. doi: 10.1085/jgp.20028639

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Copyright © 2002, The Rockefeller University Press

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Figure 4. — Response to changing external [K⁺] in channels without outer vestibule lysines. Protocols used were identical to those used in Figs. 2 and 3. (A and B) Recordings from Kv2.1 K356G K382V. (C and D) Recordings from Shaker. Currents were initially recorded in 0 mM K⁺ (shown in A and C, omitted for clarity in B and D). During the subsequent activation (dashed lines in A and C, larger currents in B and D), external [K⁺] was changed from 0 to 10 mM K⁺ (at the arrow). The third activation occurred after closing and reopening the channels in 10 mM K⁺. (E) The K⁺-dependent increase in conductance, measured from recordings as in B and D, obtained after the change in [K⁺] during the activation (black bars, O) and after closing and reopening the channels in 10 mM [K⁺] (gray bars, C-O). Bars represent seven cells in each group for Kv2.1 and K356G K382V, four cells in each group for Shaker.