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. 2002 Dec;120(6):897–906. doi: 10.1085/jgp.20028608

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Copyright © 2002, The Rockefeller University Press

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Figure 4. — Effect of UTP on Isc in the presence or absence of chloride. (A) Representative trace showing chloride dependence of the UTP (5 μM) response. Monolayers were bathed in standard porcine saline solution or chloride-free solution, replacing chloride with methane sulfonate. The peak UTP-activated current was reduced under chloride-free conditions (n = 6). (B) Bar graph showing the benzamil (5 μM) and NPPB (100 μM) -sensitive currents in the absence or presence of chloride. The NPPB-sensitive current was reduced under chloride-free conditions, whereas the benzamil-sensitive current remained the same, (n = 6 for each). Asterisk indicates significant difference between the NPPB-sensitive Isc under control and Cl⁻-free conditions.