TABLE I.

Intraburst Open and Closed States

Intraburst open states
Vm	1	τo(b)1	2	τo(b)2	3	τo(b)3	n T
mV
−50	0.552	0.15	0.439	0.391	0.009	2.607	1,993
−40	0.349	0.301	0.637	0.816	0.014	2.957	7,892
−30	0.482	0.611	0.5	1.839	0.019	4.622	5,849
−20	0.613	0.837	0.339	3.093	0.048	8.281	2,984
−10	0.407	0.646	0.494	3.11	0.1	13.864	3,337
0	0.312	1.819	0.597	8.136	0.09	23.328	554
Intraburst closed states
Vm	1	τo(b)1	2	τo(b)2	n T
mV
−50	0.517	0.63	0.483	1.585	2,093
−40	0.935	0.348	0.065	1.278	5,586
−30	0.956	0.324	0.044	1.746	3,047
−20	0.853	0.228	0.147	0.899	1,145
−10	0.819	0.37	0.181	1.543	1,334
0	0.783	0.314	0.217	1.5	169

Kinetic parameters obtained from the analysis of frequency distribution diagrams of intraburst open times (top) and intraburst closed times (bottom) of persistent Na⁺ channel openings. Data were from 10 different patches. Open-time and closed-time histograms were fitted with triple or double exponential functions, respectively (see materials and methods, Eq. 1). The fitting parameters thus obtained at various test potentials (V _m), namely time constants (τs) and relative weight coefficients (), are specified. Relative weight coefficients were calculated as: . n _T is the total number of observations in each histogram.