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. 2002 Dec;120(6):845–853. doi: 10.1085/jgp.20028699

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Copyright © 2002, The Rockefeller University Press

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Figure 5. — CaChBac_m (LDDWAD mutant) is a Ca²⁺-selective channel. (A) CaChBac_m (LDDWAD) currents in various [Ca²⁺]_o (substituted by Na⁺ to maintain isotonicity) elicited by depolarization from −100 to 0 mV. (B) Normalized current amplitude of the LDDWAD mutant plotted as a function of [Ca²⁺]_o with Na⁺ substitution (±SEM, n = 6). (C) Averaged current density-voltage relations of LDDWAD in external solutions containing 1, 10, and 105 mM Ca²⁺ (±SEM, n = 6). (D) Reversal potentials (E_rev) of the LDDWAD mutant plotted as a function of log [Ca²⁺]_o (Na⁺ substitution; ±SEM, n = 6). The slope was fitted by linear regression analysis slope (25.6 mV per decade), close to slope predicted by the Nernst equation at 22°C (29 mV).