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. 2003 Nov;122(5):521–539. doi: 10.1085/jgp.200308885

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Copyright © 2003, The Rockefeller University Press

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Figure 3. — αD97 mutations increase diliganded gating. (A) Example clusters elicited by a saturating concentration (20 mM) of choline. Most mutations increase the cluster P_open, mainly by reducing the closed-interval durations. (B) There is no apparent correlation between side chain hydrophobicity or volume and the effect on the diliganded gating equilibrium constant, L₂ (Table II).