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. 2003 Nov;122(5):501–510. doi: 10.1085/jgp.200308928

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Copyright © 2003, The Rockefeller University Press

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Figure 3. — Cd²⁺ binding is coordinated by 466C and 462C of the same subunit. (A) A tandem dimer construct with 466C and 462C in different subunits (protomer A: L466 H462C, protomer B: L466C H462Y) did not show any Cd²⁺ effect. (B) In a tandem dimer construct with 466C and 462C in the same subunit (protomer A, L466 H462Y; protomer B, L466C H462C), 130 nM Cd²⁺ produced a strong lock-open effect.