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. 2003 Nov;122(5):569–581. doi: 10.1085/jgp.200308808

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Copyright © 2003, The Rockefeller University Press

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Figure 8. — (A) Typical current traces obtained from nuclei isolated from uninjected oocytes using protocol L with pipette solution containing 10 μM InsP₃, 290 μM [Ca²⁺]_i, and 10 μM purified CaM, n = 4. (B–D) Typical current traces obtained from nuclei isolated from oocytes expressing q.m. CaM with pipette solution containing 10 μM InsP₃ and 290 μM [Ca²⁺]_i. InsP₃R channel activity was observed in 290 μM [Ca²⁺]_i in nuclei isolated by protocol L (B, n = 6) or protocol LNL (D, n = 8), but not in nuclei isolated by protocol LN (C, n = 9). Arrows indicate closed channel current levels. (E) Histogram of InsP₃R channel P _o at 10 μM InsP₃ and 290 μM [Ca²⁺]_i observed in various nuclei under experimental conditions as tabulated.