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. 2003 Nov;122(5):541–556. doi: 10.1085/jgp.200308905

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Copyright © 2003, The Rockefeller University Press

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Figure 1. — The intracellular gate region of K⁺ channels. (A) Cartoon of a voltage-gated K⁺ channel showing separate voltage-sensing and pore domains and an S6 activation gate toward the intracellular side of the pore. (B) Sequence alignment between Kv channels, KcsA, MthK and KirBac. Pink highlighting marks the conserved Gly residue that is proposed to serve as the gating hinge (Jiang et al., 2002a,b). Blue highlighting marks the position of P475 in Shaker, corresponding to P406 in Kv2.1, G229 in KvAP, A108 in KcsA, E92 in MthK, and G143 in KirBac. Green highlighting marks positions equivalent to V478 in Shaker, where Trp substitutions result in nonconducting channels (Hackos et al., 2002).