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. 2003 Nov;122(5):541–556. doi: 10.1085/jgp.200308905

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Copyright © 2003, The Rockefeller University Press

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Figure 6. — Effects of Hanatoxin on the P406D Kv2.1 channel. (A) Current records elicited by weak depolarization in control, Hanatoxin (4 μM) or Agitoxin-2 (100 nM). Traces are shown without subtraction of leak or capacitive currents. Charge carrier in the external solution was 50 mM Rb⁺. (B) G-V relations for P406D Kv2.1 Δ7 channels in the absence and presence of 4 μM Hanatoxin. Same cell as in A. Currents remaining in the presence of Agitoxin-2 have been subtracted. Smooth curves are single Boltzmann fits to the data with parameters as follows: control, V₅₀ = −51.8 mV, z = 2.8; toxin, V₅₀ = +5.7 mV, z = 2.3.