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. 2003 Dec;122(6):775–793. doi: 10.1085/jgp.200308897

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Copyright © 2003, The Rockefeller University Press

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Figure 2. — Sensitivity of heteromeric KCNQ2/3 current to extracellular H⁺ ions. (A) Whole-cell KCNQ2/3 current activation relaxations in bathing solutions of different pH were evoked by depolarizing voltage pulses (1.5 s duration) from a holding potential of −70 mV. Currents shown are from the same cell. (B) Fractional decrease of whole-cell steady-state KCNQ2/3 current in response to pH changes from pH 7.4 to the pH values indicated. Steady-state currents were measured at the end of depolarizing voltage pulses (1.5 s duration). (C) Voltage dependence of the IC₅₀ values for H⁺-induced KCNQ2/3 current decrease. Concentration-response curves were constructed for KCNQ2/3 current inhibition at each voltage and the IC₅₀ values determined at each voltage. IC₅₀ values are shown plotted against voltage. Solid line is for display purposes only.