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. 2003 Dec;122(6):657–671. doi: 10.1085/jgp.200308863

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Copyright © 2003, The Rockefeller University Press

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Figure 9. — Center and surround responses of an off-type bipolar cell recorded in a solution enriched with HEPES. (A) The current responses to a spot light (50 μm in diameter, indicated by the long horizontal bar above the response trace, duration 1,560 ms) and to surround illumination (diffuse light, 4,000 μm in diameter, superimposed on the spot light, duration 400 ms) of an off-type bipolar cell recorded under the voltage-clamp conditions (holding voltage, −40 mV). In control Ringer's solution, spot illumination evoked an outward current (suppression of the maintained inward current), while the surround illumination evoked an inward current (enhancement of the maintained inward current). The HEPES (10 mM)-enriched solution enhanced the maintained inward current (from −12 to −14 pA) and abolished the surround response. The transient inward current at the time of switch-off of spot illumination was prominently increased in HEPES buffer. The two traces were obtained from the same cell. (B) The same recordings as those shown in A in an expanded time and amplitude scale. Horizontal bars indicate the timing of the surround illumination.