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. 2003 Dec;122(6):749–760. doi: 10.1085/jgp.200308823

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Copyright © 2003, The Rockefeller University Press

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Figure 6. — Mutations at both N366 and R371 are required to confer high affinity PsTx inhibition upon CNGA3. PsTx inhibition improved slightly in 3-N366D mutant channels (15 ± 3%; n = 9), but remained almost undetectable in 3-R371Y (2 ± 1%), similar to the 2% inhibition of wild-type CNGA3. However, high-affinity inhibition (84 ± 3%; n = 4) was restored in the double mutant, 3-N366D/R371Y, beginning to approach the 94% inhibition seen in CNGA2.