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. 2003 Dec;122(6):749–760. doi: 10.1085/jgp.200308823

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Copyright © 2003, The Rockefeller University Press

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Figure 8. — PsTx inhibition of heteromeric CNG channels. (A) Currents were recorded in the whole cell patch-clamp mode from HEK-293 cells transfected with the subunit combinations indicated at the top and side. Currents were recorded at a potential of −60 mV, and the traces indicate the currents recorded in control (top), 500 nM PsTx following channel activation (middle), and 1 mM CPT-cGMP (bottom). Currents have been normalized. (B) Histogram summarizing the effects of CNG channel subunit composition on inhibition by 500 nM PsTx. Error bars indicate standard deviation and N values are noted.