Table 1.
Kelch-repeat proteins of H. sapiens
| Architecture | Domain organisation | GenBank Accession | Alternate name | Amino Acids | Chromosome localisation | Reference |
| BTB/kelch | ||||||
| BTB/K5(C) | NP_055666 | KIAA0469 | 539 | 1p36.23 | 75 | |
| BTB/K5(C) | NP_006054 | Sarcosin, KLP23, Krp1 | 606 + | 2q31.1 | 76, 77 | |
| BTB/K5(C) | AAH10437 | 558 | 2q31.1 | 78 | ||
| BTB/K5(C) | NP_115894 | Tcell activation kelch-repeat protein | 575 | 3p14 | 79 | |
| BTB/K5(C) | NP_689606 | Sarcosynapsin | 472 | 3p21.32 | ||
| BTB/K5(C) | NP_060114 | 412 | 3q27.3 | |||
| BTB/K5(C) | XP_291224 | KIAA1489 | 623 | 7p14.3 | ||
| BTB/K5(C) | XP_063481 * | 819 | 14q11.1 | |||
| BTB/K5(C) | XP_171687 * | 458 $ | 15q21.2 | |||
| BTB/K6(C) | NP_005888 | IPP | 584 | 1p32 | 80 | |
| BTB/K6(C) | NP_055273 | Kelch motif-containing protein, KLX | 609 | 1q24.1-24.3 | ||
| BTB/K6(C) | NP_006460 | NS1-binding protein, Nd1 orthologue | 642 | 1q25.1 | 81, 82 | |
| BTB/K6(C) | NP_067646 | Kelch-like protein C3IP1 | 568 | 1q31.3 | ||
| BTB/K6(C) | BAB67814 | KIAA1921 | 545 | 2p23.2 | 83 | |
| BTB/K6(C) | XP_292990 | 649 | 2q37.3 | |||
| BTB/K6(C) | XP_093813 * | 585 | 3q21.3 | |||
| BTB/K6(C) | BAB93503 | 509 | 3p21.31 | |||
| BTB/K6(C) | NP_569713 | KLHL6 | 610 | 3q27.3 | 84, 85 | |
| BTB/K6(C) | NP_057074 | KLHL5, lymphocyte activation-associated protein | 734 @ | 4p15.1 | 86 | |
| BTB/K6(C) | NP_009177 | Mayven, KLP2 | 593 | 4q21.2 | 87 | |
| BTB/K6(C) | NP_065854 | KLHL8 | 620 | 4q21.3 | 88 | |
| BTB/K6(C) | NP_003624 | ENC-1, Nrp/b | 589 | 5q12-q13.3 | 89, 90 | |
| BTB/K6(C) | NP_059111 | KLHL3 | 587 | 5q31 | 91, 92 | |
| BTB/K6(C) | CAC16284 | 634 | 6p12.1 | |||
| BTB/K6(C) | NP_443136 | KIAA1900 | 620 | 6q16.3 | 93 | |
| BTB/K6(C) | NP_061334 | 564 | 7q15.3 | |||
| BTB/K6(C) | NP_055682 | KIAA0711 | 623 | 8p23.2 | 94 | |
| BTB/K6(?) | XP_294387 * | 649 | 8q24.13 | |||
| BTB/K6(C) | NP_005884 | Calicin | 588 | 9p11.2 | 95 | |
| BTB/K6(C) | NP_061335 | KIAA1354 | 617 | 9p22 | 88 | |
| BTB/K6(C) | NP_060565 | 518 | 11p11.12 | |||
| BTB/K6(C) | AAH42952 | 431(a) | 11q13.3 | |||
| BTB/K6(C) | NP_689646 | 608 | 11q22.3 | |||
| BTB/K6(C) | XP_044836 | 505 | 12q11.23 | |||
| BTB/K6(C) | NP_115514 | 684 | 13q13.3 | 96 | ||
| BTB/K6(C) | NP_065917 | KLHL1 | 748 | 13q21 | 97 | |
| BTB/K6(C) | XP_058629 * | 309(b) | 14q21.1 | |||
| BTB/K6(C) | NP_071925 | 589 | 15q25.2 | |||
| BTB/K6(C) | NP_079007 | 616 | 16q23.3 | |||
| BTB/K6(C) | NP_071324 | gigaxonin | 597 | 16q24.1 | 98 | |
| BTB/K6(C) | NP_689680 | KLHL10 | 614 | 17q21.2 | ||
| BTB/K6(C) | NP_060613 | 708 | 17q21.2 | |||
| BTB/K6(C) | spQ9P2G3 * | KIAA1384 | 628 | 18q12.1 | 88 | |
| BTB/K6(C) | NP_060786 | 615 | 19p13.11 | |||
| BTB/K6(C) | NP_036421 | Keap1 | 624 | 19p13.2 | 98, 99 | |
| BTB/K6(C) | NP_116164 | 634 | 22q11.21 | |||
| BTB/K6(C) | NP_695002 | 644 | Xp22.13 | |||
| BTB/K6(C) | NP_476503 | KLHL4 | 720 | Xq21.3 | 100 | |
| BTB/K6(C) | XP_040383 | KIAA1677 | 604 | Xq22.1-q21 | ||
| BTB/K6(C) | spQ9P2N7 | KIAA1309 | 639 | Xq23-q24 | ||
| K6/BTBx2(N) | NP_006758 | LZTR-1 ^ | 552 | 22q11.21 | 69 | |
| Discoidin/kelch | ||||||
| DD/K6(N) | NP_037387 * | muskelin | 735 | 7q32 | 71 | |
| F-box/kelch | ||||||
| F-box/K5(N) | XP_048774 | KIAA1332 | 717 | 1p36.13 | ||
| LCM/kelch | ||||||
| LCM/K6(?) | NP_055608 * | p21Waf/CIPpromoter-binding protein | 686 | 15q14 | 26 | |
| Kelch and PHD | ||||||
| K6/u/PHD(N) | NP_000527 * | RAG-2 | 527 | 11p13 | 16 | |
| Kelch and multidomain | ||||||
| K6/HCF/FNIII | NP_005325 | Host cell factor-1(N) | 1938 | Xq28 | 30 | |
| CUB/DSL/K4? | CAC12966 | 510 | 10q26.11 | |||
| K5/CL(C) | BAA25460 | KIAA0543 | 1011 | 10q26 | 101 | |
| K6/FNIII(N) | NP_037452 | Host cell factor-2 | 792 | 12q23.3 | 31 | |
| CUB/K6/E(N) | PIRT00209 | MEGF8, pregnancy-specific β 1 glycoprotein | 1737 + | 19q12 | 102 | |
| CB/K6/CL(N) | NP_647537 * | Attractin, mahogany | 1198, 1429 + | 20p13 | 27–29 | |
| Kelch and unique | ||||||
| u/K6(C) | NP_689588 | 559 | 1p36.13 | |||
| K6/u(N,?) | NP_060036 | 520 | 16q24.3 | |||
| u/K5(C) | NP_612442 | 495 | 22q13.33 | |||
| Propeller only | ||||||
| K7(N) | NP_060673 | 350 | 1q32.1 | |||
| K7(N) | NP_775817 * | 354 | 3p21.21 | |||
| K6(N,?) | NP_476502 | PEAS, TIM | 382 | 6p21.1 | 103 | |
| K6(C) | XP_045954 | KIAA0265 | 442 | 7q32.2 | ||
| K6(N) | NP_005824 | p40 Rab9 effector | 372 | 9q34.21 | 32 | |
| K6(C) | NP_055130 | HCLP-1, Kelch domain-containing 2 | 406 | 14q21.3 | 104 | |
| K6(?) | NP_751943 | Kelch domain-containing 1 | 406 | 14q21.3 |
Key. + Splice variants reported. $ No EST match. @spQ96PQ7 encodes a longer protein of 755 amino acids. ^Human LZTR-1 sequence lacks amino-terminus included in mouse NP_080084. (a), human sequence not full-length, mouse orthologue (BAB28596, >90% identity, 574aa) contains a BTB domain (b), human sequence not full-length, mouse orthologue (NP_079983, >90% identity, 571aa) contains a BTB domain. *Kelch-repeat proteins not listed in either Pfam or SMART species trees. Additional domains listed include C-type lectin (CL); C1r, C1s, uEGF, and bone morphogenetic protein domain (CUB or CB); delta serrate ligand (DSL); epidermal growth factor (EGF); fibronectin type III repeats (FNIII); HCF repeats (HCF).