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. 2004 Jul;124(1):71–81. doi: 10.1085/jgp.200409048

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Copyright © 2004, The Rockefeller University Press

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Figure 2. — κ-PVIIA block of Shaker currents in symmetric and asymmetric ionic Rb⁺ or K⁺ solutions. Current records in response to IV protocols (V_H = −100 mV, V_P from −50 mV to +70 mV, every 20 mV) recorded with outside-out patch clamp experiments in symmetrical 115 mM KCl (top left), symmetrical 115 mM RbCl (top right), K_ext/Rb_int (bottom left), and Rb_ext/K_int (bottom right) before and after the addition to the bath of κ-PVIIA (concentration indicated in the figure). The reversal potential is +5 mV in symmetrical 115 mM KCl, +3 mV in symmetrical 115 mM RbCl, +4 mV in K_ext/Rb_int, and −5 mV in Rb_ext/K_int.