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. 2004 Jul;124(1):71–81. doi: 10.1085/jgp.200409048

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Copyright © 2004, The Rockefeller University Press

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Figure 5. — Cartoon of κ-PVIIA binding to Shaker K⁺ channels in the presence of Rb⁺ or K⁺. κ-PVIIA binding interacts differently with the ion(s)–channel complex depending on the state of the channel (top panel, closed state; bottom panel, open state) and on the pore occupancy of the permeant ion species (left panel, K⁺; right panel, Rb⁺). Ion binding sites within the selectivity filter are numbered from 1 to 4, while S0 is the extracellular binding site for K⁺. A detailed description is given in the Discussion.