Table 5.
Tetra-nucleotide bias for three RNA viruses. The tetra-nucleotide bias in three viruses. z value quantifies the tetra-nucleotide bias, as defined in equation (1). N (w) and E (w) are actual and expected frequency of occurrence for word w.
| BCoV | MHV | SARS | BCoV | MHV | SARS | ||||||||||||||
| Tetra-nucleotide | N(w) | E(w) | z | N(w) | E(w) | z | N(w) | E(w) | z | Tetra-nucleotide | N(w) | E(w) | z | N(w) | E(w) | z | N(w) | E(w) | z |
| AAAA | 148 | 206.2 | -7.4 | 147 | 145.8 | 0.2 | 222 | 216.5 | 0.7 | UAAA | 264 | 226.2 | 4.6 | 187 | 170.9 | 2.2 | 170 | 183 | -1.7 |
| AAAC | 110 | 103.7 | 1.1 | 98 | 91.2 | 1.3 | 154 | 148.1 | 0.9 | UAAC | 78 | 105.1 | -4.8 | 85 | 122.4 | -6.1 | 123 | 128 | -0.8 |
| AAAG | 184 | 169.7 | 2.0 | 173 | 133.6 | 6.2 | 165 | 158.8 | 0.9 | UAAG | 205 | 171.7 | 4.6 | 193 | 165.3 | 3.9 | 107 | 134.4 | -4.3 |
| AAAU | 217 | 220 | -0.4 | 179 | 164.9 | 2.0 | 213 | 200.6 | 1.6 | UAAU | 322 | 309.9 | 1.3 | 245 | 259.8 | -1.7 | 166 | 193.9 | -3.6 |
| AACA | 133 | 114.1 | 3.2 | 113 | 112.1 | 0.2 | 215 | 175.7 | 5.4 | UACA | 178 | 163.7 | 2.0 | 122 | 123.4 | -0.2 | 230 | 200.3 | 3.8 |
| AACC | 76 | 61.3 | 3.4 | 107 | 75.2 | 6.7 | 102 | 92.5 | 1.8 | UACC | 97 | 82.9 | 2.8 | 106 | 98.5 | 1.4 | 118 | 97.1 | 3.8 |
| AACG | 29 | 40.7 | -3.3 | 35 | 61.8 | -6.2 | 44 | 66.3 | -5.0 | UACG | 50 | 54.4 | -1.1 | 58 | 72.6 | -3.1 | 46 | 63.3 | -3.9 |
| AACU | 91 | 121.5 | -5.0 | 84 | 106.5 | -4.0 | 171 | 168.5 | 0.4 | UACU | 196 | 205.2 | -1.2 | 153 | 168.2 | -2.1 | 195 | 192.2 | 0.4 |
| AAGA | 172 | 157.9 | 2.0 | 176 | 136.4 | 6.2 | 184 | 161.8 | 3.2 | UAGA | 128 | 123.4 | 0.8 | 119 | 124.7 | -0.9 | 102 | 119.6 | -2.9 |
| AAGC | 137 | 103.8 | 5.9 | 140 | 103 | 6.6 | 96 | 112.8 | -2.9 | UAGC | 79 | 98.7 | -3.6 | 82 | 118.7 | -6.1 | 71 | 84.8 | -2.7 |
| AAGG | 133 | 121.3 | 1.9 | 159 | 122.4 | 6.0 | 140 | 117.3 | 3.8 | UAGG | 73 | 78.8 | -1.2 | 67 | 121.3 | -9.0 | 74 | 75.6 | -0.3 |
| AAGU | 191 | 180.6 | 1.4 | 179 | 163.1 | 2.3 | 136 | 139.4 | -0.5 | UAGU | 171 | 213 | -5.2 | 161 | 190.7 | -3.9 | 101 | 126.8 | -4.2 |
| AAUA | 189 | 215.2 | -3.2 | 148 | 182.1 | -4.6 | 113 | 154.1 | -6.0 | UAUA | 251 | 237 | 1.7 | 192 | 189 | 0.4 | 99 | 136.5 | -5.8 |
| AAUC | 100 | 104.5 | -0.8 | 75 | 93.2 | -3.4 | 93 | 121.9 | -4.8 | UAUC | 84 | 112.3 | -4.9 | 86 | 99.9 | -2.5 | 84 | 116.1 | -5.4 |
| AAUG | 246 | 229.3 | 2.0 | 234 | 232.1 | 0.2 | 230 | 201.5 | 3.7 | UAUG | 310 | 271.5 | 4.3 | 278 | 238.1 | 4.7 | 189 | 190.3 | -0.2 |
| AAUU | 265 | 265.5 | -0.1 | 212 | 207.8 | 0.5 | 211 | 212 | -0.1 | UAUU | 314 | 345 | -3.0 | 253 | 248.5 | 0.5 | 190 | 211.8 | -2.7 |
| ACAA | 144 | 137.1 | 1.1 | 115 | 114.1 | 0.2 | 269 | 204.1 | 8.3 | UCAA | 131 | 130 | 0.2 | 136 | 117.7 | 3.1 | 202 | 174.1 | 3.8 |
| ACAC | 84 | 66.4 | 3.9 | 88 | 75.4 | 2.6 | 168 | 142.2 | 3.9 | UCAC | 53 | 60.4 | -1.7 | 57 | 67.1 | -2.2 | 130 | 109.6 | 3.5 |
| ACAG | 118 | 105.7 | 2.2 | 108 | 104.9 | 0.5 | 151 | 145.1 | 0.9 | UCAG | 107 | 122.1 | -2.5 | 105 | 106.7 | -0.3 | 110 | 121.4 | -1.9 |
| ACAU | 128 | 123.5 | 0.7 | 106 | 122.7 | -2.7 | 186 | 172.9 | 1.8 | UCAU | 84 | 124.6 | -6.6 | 88 | 117.8 | -5.0 | 153 | 146.7 | 0.9 |
| ACCA | 105 | 76.9 | 5.8 | 116 | 85 | 6.1 | 161 | 117.7 | 7.3 | UCCA | 68 | 73.4 | -1.1 | 74 | 80.6 | -1.3 | 76 | 95.4 | -3.6 |
| ACCC | 56 | 37.3 | 5.6 | 84 | 57.6 | 6.3 | 54 | 60.7 | -1.6 | UCCC | 31 | 37.4 | -1.9 | 45 | 56 | -2.7 | 31 | 44.6 | -3.7 |
| ACCG | 24 | 35.5 | -3.5 | 52 | 57.4 | -1.3 | 31 | 48.8 | -4.6 | UCCG | 15 | 26 | -3.9 | 37 | 55.1 | -4.4 | 19 | 29.7 | -3.5 |
| ACCU | 83 | 77.7 | 1.1 | 97 | 97.7 | -0.1 | 139 | 111.2 | 4.8 | UCCU | 74 | 101.4 | -4.9 | 103 | 102.4 | 0.1 | 80 | 107.1 | -4.8 |
| ACGA | 32 | 44.5 | -3.4 | 31 | 56.5 | -6.2 | 40 | 64.4 | -5.5 | UCGA | 18 | 41.4 | -6.6 | 42 | 50.4 | -2.2 | 43 | 67.5 | -5.4 |
| ACGC | 29 | 34.1 | -1.6 | 49 | 52.5 | -0.9 | 31 | 54.8 | -5.8 | UCGC | 30 | 34.1 | -1.3 | 45 | 54 | -2.2 | 38 | 56.2 | -4.4 |
| ACGG | 26 | 31.3 | -1.7 | 46 | 48.5 | -0.7 | 26 | 41 | -4.2 | UCGG | 19 | 29.1 | -3.4 | 33 | 49.8 | -4.3 | 16 | 39.9 | -6.9 |
| ACGU | 47 | 60.5 | -3.1 | 53 | 72.1 | -4.1 | 53 | 72.6 | -4.2 | UCGU | 51 | 74.1 | -4.9 | 59 | 74.8 | -3.3 | 73 | 84.4 | -2.3 |
| ACUA | 141 | 127.9 | 2.1 | 119 | 121.3 | -0.4 | 166 | 167.3 | -0.2 | UCUA | 116 | 130.2 | -2.3 | 115 | 124.5 | -1.5 | 130 | 140.9 | -1.7 |
| ACUC | 49 | 68.2 | -4.2 | 61 | 68.9 | -1.7 | 119 | 115 | 0.7 | UCUC | 52 | 67.1 | -3.3 | 69 | 69.6 | -0.1 | 82 | 108.4 | -4.6 |
| ACUG | 144 | 131.5 | 2.0 | 126 | 141.4 | -2.4 | 159 | 163.3 | -0.6 | UCUG | 119 | 135.5 | -2.6 | 117 | 135.5 | -2.9 | 133 | 141.4 | -1.3 |
| ACUU | 142 | 160.9 | -2.7 | 116 | 132.1 | -2.5 | 207 | 184.9 | 3.0 | UCUU | 195 | 191.8 | 0.4 | 153 | 142.8 | 1.6 | 219 | 182.6 | 4.9 |
| AGAA | 147 | 141.6 | 0.8 | 162 | 126.6 | 5.7 | 144 | 158.7 | -2.1 | UGAA | 174 | 195.3 | -2.8 | 154 | 176.8 | -3.1 | 164 | 180.2 | -2.2 |
| AGAC | 67 | 71.9 | -1.1 | 87 | 80.6 | 1.3 | 114 | 117.2 | -0.5 | UGAC | 86 | 101.8 | -2.8 | 118 | 127.6 | -1.5 | 153 | 151.9 | 0.2 |
| AGAG | 107 | 88.9 | 3.5 | 115 | 103.4 | 2.1 | 146 | 112.3 | 5.8 | UGAG | 96 | 127.7 | -5.1 | 144 | 167 | -3.2 | 117 | 136.2 | -3.0 |
| AGAU | 177 | 170.4 | 0.9 | 158 | 145.2 | 1.9 | 128 | 141.1 | -2.0 | UGAU | 314 | 311.7 | 0.2 | 243 | 261 | -2.0 | 215 | 196.5 | 2.4 |
| AGCA | 113 | 105.8 | 1.3 | 102 | 112.1 | -1.7 | 105 | 118.8 | -2.3 | UGCA | 181 | 166.3 | 2.1 | 187 | 161.5 | 3.6 | 166 | 182 | -2.2 |
| AGCC | 77 | 54.1 | 5.7 | 91 | 80.7 | 2.1 | 68 | 55.4 | 3.1 | UGCC | 102 | 81.6 | 4.1 | 144 | 122.4 | 3.6 | 114 | 81.6 | 6.5 |
| AGCG | 48 | 44.9 | 0.8 | 62 | 71.2 | -2.0 | 32 | 46.4 | -3.8 | UGCG | 52 | 65.5 | -3.0 | 86 | 97.6 | -2.1 | 58 | 58.5 | -0.1 |
| AGCU | 126 | 122.6 | 0.6 | 132 | 132 | 0.0 | 140 | 146.9 | -1.0 | UGCU | 270 | 218.4 | 6.4 | 254 | 226.8 | 3.3 | 315 | 224.5 | 11.0 |
| AGGA | 116 | 96.4 | 3.6 | 114 | 117.8 | -0.6 | 138 | 99.5 | 7.0 | UGGA | 171 | 154.4 | 2.4 | 187 | 147.4 | 5.9 | 152 | 126 | 4.2 |
| AGGC | 65 | 61.9 | 0.7 | 114 | 104.6 | 1.7 | 92 | 80.3 | 2.4 | UGGC | 144 | 103.8 | 7.2 | 184 | 144.4 | 6.0 | 141 | 103.4 | 6.7 |
| AGGG | 55 | 59.1 | -1.0 | 88 | 79.5 | 1.7 | 53 | 60.7 | -1.8 | UGGG | 81 | 105 | -4.3 | 90 | 118.9 | -4.8 | 59 | 74.4 | -3.2 |
| AGGU | 137 | 143.8 | -1.0 | 128 | 150 | -3.3 | 129 | 119.5 | 1.6 | UGGU | 307 | 302.3 | 0.5 | 260 | 236.3 | 2.8 | 200 | 173.5 | 3.7 |
| AGUA | 137 | 159.2 | -3.2 | 124 | 155.6 | -4.6 | 115 | 116.9 | -0.3 | UGUA | 228 | 233.8 | -0.7 | 202 | 215.5 | -1.7 | 161 | 165.6 | -0.6 |
| AGUC | 62 | 77.6 | -3.2 | 75 | 93.9 | -3.5 | 76 | 87.3 | -2.2 | UGUC | 116 | 116.5 | -0.1 | 159 | 143.6 | 2.3 | 141 | 129.8 | 1.8 |
| AGUG | 152 | 156.2 | -0.6 | 187 | 173.8 | 1.8 | 127 | 120.7 | 1.0 | UGUG | 266 | 246.9 | 2.2 | 300 | 255.8 | 5.0 | 214 | 170.9 | 6.0 |
| AGUU | 222 | 239.6 | -2.1 | 214 | 206 | 1.0 | 126 | 161.7 | -5.1 | UGUU | 498 | 407.8 | 8.1 | 415 | 346.1 | 6.7 | 274 | 252 | 2.5 |
| AUAA | 228 | 220.7 | 0.9 | 189 | 188.5 | 0.1 | 129 | 152.4 | -3.4 | UUAA | 322 | 269.8 | 5.8 | 258 | 235.5 | 2.7 | 195 | 202.8 | -1.0 |
| AUAC | 124 | 129.2 | -0.8 | 100 | 112.8 | -2.2 | 100 | 132.3 | -5.1 | UUAC | 185 | 173.5 | 1.6 | 158 | 155.6 | 0.3 | 186 | 179.8 | 0.8 |
| AUAG | 120 | 141.9 | -3.3 | 120 | 135 | -2.3 | 65 | 91.7 | -5.1 | UUAG | 141 | 177.5 | -5.0 | 131 | 183 | -7.0 | 112 | 119.5 | -1.2 |
| AUAU | 205 | 237.9 | -3.9 | 151 | 185.9 | -4.7 | 99 | 144.4 | -6.9 | UUAU | 397 | 385.6 | 1.1 | 309 | 269.1 | 4.4 | 191 | 226.5 | -4.3 |
| AUCA | 105 | 122 | -2.8 | 77 | 99.2 | -4.1 | 139 | 136.8 | 0.3 | UUCA | 127 | 155 | -4.1 | 132 | 126.1 | 1.0 | 206 | 180 | 3.5 |
| AUCC | 59 | 62.9 | -0.9 | 63 | 65.5 | -0.6 | 54 | 65.9 | -2.7 | UUCC | 66 | 80.1 | -2.9 | 75 | 90.9 | -3.0 | 71 | 87.9 | -3.3 |
| AUCG | 31 | 46.9 | -4.2 | 42 | 57.2 | -3.7 | 31 | 59.6 | -6.7 | UUCG | 33 | 55.3 | -5.5 | 64 | 69.3 | -1.2 | 56 | 71.8 | -3.4 |
| AUCU | 108 | 129.1 | -3.4 | 87 | 109.2 | -3.9 | 108 | 137.1 | -4.5 | UUCU | 193 | 201.6 | -1.1 | 133 | 151.2 | -2.7 | 226 | 189.5 | 4.8 |
| AUGA | 204 | 212.3 | -1.0 | 203 | 202.8 | 0.0 | 189 | 198.6 | -1.2 | UUGA | 237 | 239.3 | -0.3 | 197 | 213.4 | -2.0 | 189 | 186.8 | 0.3 |
| AUGC | 186 | 151.1 | 5.2 | 194 | 164.2 | 4.2 | 179 | 154.3 | 3.6 | UUGC | 197 | 174.1 | 3.2 | 188 | 184.4 | 0.5 | 185 | 162.5 | 3.2 |
| AUGG | 211 | 180.8 | 4.1 | 197 | 179.4 | 2.4 | 185 | 143.1 | 6.4 | UUGG | 213 | 230.6 | -2.1 | 208 | 185.6 | 3.0 | 153 | 143.2 | 1.5 |
| AUGU | 296 | 273.3 | 2.5 | 275 | 269.9 | 0.6 | 218 | 197.4 | 2.7 | UUGU | 415 | 363.3 | 4.9 | 368 | 298 | 7.4 | 245 | 204.3 | 5.2 |
| AUUA | 239 | 253.9 | -1.7 | 191 | 216 | -3.1 | 190 | 192 | -0.3 | UUUA | 407 | 345.3 | 6.0 | 303 | 257.1 | 5.2 | 204 | 204.1 | 0.0 |
| AUUC | 106 | 126.1 | -3.3 | 100 | 110.2 | -1.8 | 127 | 136.8 | -1.5 | UUUC | 141 | 161.3 | -2.9 | 109 | 146.1 | -5.6 | 187 | 162.4 | 3.5 |
| AUUG | 245 | 253.5 | -1.0 | 206 | 211.6 | -0.7 | 208 | 176 | 4.4 | UUUG | 367 | 357.7 | 0.9 | 318 | 271.3 | 5.2 | 207 | 194.8 | 1.6 |
| AUUU | 361 | 337.8 | 2.3 | 287 | 251.6 | 4.1 | 197 | 205.6 | -1.1 | UUUU | 454 | 495.8 | -3.4 | 296 | 325 | -2.9 | 215 | 245.2 | -3.5 |
| GAAA | 118 | 124 | -1.0 | 104 | 111.4 | -1.3 | 142 | 140.8 | 0.2 | CAAA | 128 | 133.8 | -0.9 | 160 | 108.5 | 9.0 | 221 | 182.3 | 5.2 |
| GAAC | 58 | 64.6 | -1.5 | 63 | 75.1 | -2.5 | 89 | 96.9 | -1.5 | CAAC | 83 | 71 | 2.6 | 93 | 74.9 | 3.8 | 166 | 128.5 | 6.0 |
| GAAG | 136 | 125.8 | 1.7 | 153 | 123.2 | 4.9 | 126 | 117.7 | 1.4 | CAAG | 108 | 111 | -0.5 | 135 | 111.5 | 4.0 | 158 | 132.5 | 4.0 |
| GAAU | 118 | 140.8 | -3.5 | 119 | 142.4 | -3.6 | 90 | 125.7 | -5.8 | CAAU | 144 | 147.5 | -0.5 | 126 | 139.1 | -2.0 | 178 | 170.2 | 1.1 |
| GACA | 82 | 83 | -0.2 | 99 | 91 | 1.5 | 162 | 128.5 | 5.4 | CACA | 82 | 78.3 | 0.8 | 84 | 80.6 | 0.7 | 168 | 150.9 | 2.5 |
| GACC | 37 | 39.2 | -0.6 | 61 | 69.1 | -1.8 | 66 | 68.5 | -0.5 | CACC | 59 | 44 | 4.1 | 76 | 59.3 | 3.9 | 98 | 80.1 | 3.6 |
| GACG | 27 | 33 | -1.9 | 46 | 51 | -1.3 | 33 | 52.9 | -5.0 | CACG | 28 | 31.5 | -1.1 | 40 | 46 | -1.6 | 27 | 50.4 | -6.0 |
| GACU | 82 | 86.6 | -0.9 | 88 | 94.7 | -1.3 | 101 | 115.3 | -2.4 | CACU | 108 | 75.3 | 6.8 | 97 | 93.1 | 0.7 | 184 | 151.4 | 4.8 |
| GAGA | 73 | 77.8 | -1.0 | 104 | 100.3 | 0.7 | 105 | 111.8 | -1.2 | CAGA | 125 | 106.4 | 3.3 | 123 | 98.1 | 4.6 | 141 | 128.8 | 2.0 |
| GAGC | 52 | 60.1 | -1.9 | 66 | 90.9 | -4.8 | 83 | 74.9 | 1.7 | CAGC | 96 | 71.9 | 5.2 | 99 | 82.8 | 3.2 | 95 | 96.6 | -0.3 |
| GAGG | 73 | 68.6 | 1.0 | 112 | 108.6 | 0.6 | 95 | 89.1 | 1.1 | CAGG | 94 | 84.9 | 1.8 | 106 | 93.4 | 2.4 | 102 | 93.4 | 1.6 |
| GAGU | 103 | 100.9 | 0.4 | 128 | 134 | -0.9 | 108 | 98.6 | 1.7 | CAGU | 108 | 128.7 | -3.3 | 132 | 127.4 | 0.7 | 98 | 127.2 | -4.7 |
| GAUA | 149 | 172.1 | -3.2 | 127 | 145.4 | -2.8 | 81 | 111 | -5.2 | CAUA | 88 | 110.8 | -3.9 | 92 | 112.5 | -3.5 | 99 | 118.2 | -3.2 |
| GAUC | 70 | 86.1 | -3.2 | 63 | 73 | -2.1 | 55 | 75.7 | -4.3 | CAUC | 49 | 56.5 | -1.8 | 45 | 67.1 | -4.9 | 100 | 91.9 | 1.5 |
| GAUG | 231 | 209.7 | 2.7 | 237 | 199.5 | 4.8 | 198 | 159 | 5.6 | CAUG | 110 | 117.8 | -1.3 | 119 | 143.9 | -3.8 | 153 | 138.3 | 2.3 |
| GAUU | 205 | 201.7 | 0.4 | 159 | 176.8 | -2.4 | 125 | 128.6 | -0.6 | CAUU | 166 | 149 | 2.5 | 160 | 159 | 0.1 | 196 | 173 | 3.2 |
| GCAA | 104 | 114.7 | -1.8 | 137 | 123.3 | 2.2 | 133 | 131 | 0.3 | CCAA | 84 | 81.4 | 0.5 | 126 | 90.8 | 6.7 | 119 | 107.2 | 2.1 |
| GCAC | 70 | 65.3 | 1.1 | 77 | 74.2 | 0.6 | 99 | 92 | 1.3 | CCAC | 71 | 41.7 | 8.2 | 74 | 55.9 | 4.4 | 81 | 77.7 | 0.7 |
| GCAG | 131 | 102.4 | 5.1 | 157 | 113.3 | 7.5 | 80 | 100.5 | -3.7 | CCAG | 67 | 64.5 | 0.6 | 90 | 80.7 | 1.9 | 95 | 77.5 | 3.6 |
| GCAU | 120 | 109.4 | 1.8 | 128 | 140.9 | -2.0 | 112 | 104.2 | 1.4 | CCAU | 81 | 71.9 | 1.9 | 94 | 97.4 | -0.6 | 97 | 91 | 1.1 |
| GCCA | 84 | 57.8 | 6.2 | 111 | 97.4 | 2.5 | 99 | 76.5 | 4.7 | CCCA | 46 | 41.6 | 1.2 | 83 | 62.7 | 4.7 | 56 | 60.1 | -1.0 |
| GCCC | 34 | 34.5 | -0.2 | 75 | 63.8 | 2.5 | 35 | 36.6 | -0.5 | CCCC | 28 | 22.2 | 2.2 | 43 | 47.5 | -1.2 | 18 | 28.8 | -3.6 |
| GCCG | 29 | 29.7 | -0.2 | 51 | 60.5 | -2.2 | 21 | 31.7 | -3.4 | CCCG | 17 | 20.4 | -1.4 | 45 | 39.4 | 1.6 | 16 | 20.1 | -1.6 |
| GCCU | 84 | 66.8 | 3.8 | 122 | 106.2 | 2.8 | 75 | 71.9 | 0.7 | CCCU | 58 | 43.9 | 3.8 | 76 | 78 | -0.4 | 48 | 60.7 | -3.0 |
| GCGA | 30 | 38.9 | -2.6 | 42 | 57.3 | -3.7 | 36 | 43.5 | -2.1 | CCGA | 25 | 27.9 | -1.0 | 45 | 47.1 | -0.6 | 16 | 36.2 | -6.0 |
| GCGC | 31 | 31.7 | -0.2 | 65 | 57.4 | 1.8 | 38 | 41 | -0.8 | CCGC | 20 | 21.8 | -0.7 | 50 | 47 | 0.8 | 21 | 32.1 | -3.6 |
| GCGG | 21 | 31.7 | -3.4 | 43 | 56.8 | -3.3 | 23 | 29.6 | -2.2 | CCGG | 11 | 20.9 | -3.9 | 36 | 44.9 | -2.4 | 13 | 21.2 | -3.2 |
| GCGU | 63 | 55.9 | 1.7 | 87 | 82.1 | 1.0 | 47 | 52.9 | -1.5 | CCGU | 29 | 38.2 | -2.7 | 54 | 68.1 | -3.1 | 37 | 41.8 | -1.3 |
| GCUA | 165 | 131.3 | 5.4 | 162 | 144.3 | 2.7 | 153 | 140.7 | 1.9 | CCUA | 85 | 77 | 1.7 | 83 | 96.5 | -2.5 | 104 | 88.6 | 3.0 |
| GCUC | 58 | 58.8 | -0.2 | 75 | 80.5 | -1.1 | 89 | 98.1 | -1.7 | CCUC | 38 | 40.1 | -0.6 | 79 | 58.6 | 4.8 | 63 | 65.2 | -0.5 |
| GCUG | 136 | 131.5 | 0.7 | 187 | 173.4 | 1.9 | 196 | 145.3 | 7.6 | CCUG | 89 | 80.4 | 1.7 | 118 | 108.1 | 1.7 | 70 | 89 | -3.7 |
| GCUU | 167 | 147.3 | 3.0 | 158 | 162.5 | -0.6 | 180 | 149.5 | 4.5 | CCUU | 86 | 97.4 | -2.1 | 119 | 113.3 | 1.0 | 105 | 104.6 | 0.1 |
| GGAA | 86 | 82.1 | 0.8 | 83 | 103.4 | -3.7 | 103 | 86 | 3.3 | CGAA | 23 | 42.7 | -5.5 | 40 | 58.5 | -4.4 | 37 | 55.5 | -4.5 |
| GGAC | 51 | 48.4 | 0.7 | 57 | 67.7 | -2.4 | 68 | 72.3 | -0.9 | CGAC | 24 | 22.5 | 0.6 | 32 | 34.3 | -0.7 | 27 | 46.9 | -5.3 |
| GGAG | 81 | 66.6 | 3.2 | 109 | 95.9 | 2.4 | 92 | 70.1 | 4.8 | CGAG | 17 | 29.5 | -4.2 | 42 | 53.5 | -2.9 | 35 | 49.8 | -3.8 |
| GGAU | 122 | 127 | -0.8 | 139 | 124.7 | 2.3 | 80 | 83.7 | -0.7 | CGAU | 41 | 63.1 | -5.0 | 46 | 63.3 | -4.0 | 36 | 56 | -4.9 |
| GGCA | 93 | 70 | 5.0 | 142 | 99.4 | 7.7 | 108 | 83.7 | 4.8 | CGCA | 38 | 40.7 | -0.8 | 67 | 63.3 | 0.8 | 46 | 58.2 | -2.9 |
| GGCC | 34 | 33.7 | 0.1 | 74 | 74.8 | -0.2 | 33 | 39.1 | -1.8 | CGCC | 19 | 17.1 | 0.8 | 50 | 45.6 | 1.2 | 15 | 27.1 | -4.2 |
| GGCG | 28 | 32.2 | -1.3 | 57 | 62.9 | -1.4 | 33 | 40.5 | -2.1 | CGCG | 17 | 14.9 | 1.0 | 32 | 39.2 | -2.1 | 21 | 23.4 | -0.9 |
| GGCU | 95 | 88.7 | 1.2 | 135 | 117.9 | 2.9 | 115 | 94.9 | 3.8 | CGCU | 36 | 44.4 | -2.3 | 61 | 73.5 | -2.7 | 46 | 74.1 | -5.9 |
| GGGA | 38 | 53 | -3.7 | 52 | 65.7 | -3.1 | 36 | 48.5 | -3.3 | CGGA | 15 | 26.4 | -4.0 | 35 | 51 | -4.1 | 18 | 33.8 | -4.9 |
| GGGC | 20 | 37.4 | -5.1 | 64 | 68.8 | -1.1 | 36 | 38.3 | -0.7 | CGGC | 21 | 19 | 0.8 | 45 | 47.2 | -0.6 | 20 | 29.3 | -3.1 |
| GGGG | 26 | 41.9 | -4.5 | 23 | 53.8 | -7.6 | 20 | 31.4 | -3.7 | CGGG | 10 | 19.9 | -4.0 | 27 | 39.1 | -3.5 | 12 | 17.5 | -2.4 |
| GGGU | 88 | 95 | -1.3 | 88 | 100.4 | -2.2 | 52 | 63.8 | -2.7 | CGGU | 31 | 50.2 | -4.9 | 52 | 67.2 | -3.4 | 28 | 55.5 | -6.7 |
| GGUA | 147 | 153.8 | -1.0 | 113 | 130.8 | -2.8 | 106 | 102.8 | 0.6 | CGUA | 55 | 53.6 | 0.3 | 52 | 71.6 | -4.2 | 52 | 60.2 | -1.9 |
| GGUC | 51 | 70.4 | -4.2 | 61 | 76.8 | -3.3 | 40 | 71.3 | -6.7 | CGUC | 16 | 24.9 | -3.2 | 29 | 41.9 | -3.6 | 36 | 41.9 | -1.6 |
| GGUG | 160 | 161.8 | -0.3 | 179 | 171.9 | 1.0 | 135 | 119.9 | 2.5 | CGUG | 60 | 64.9 | -1.1 | 84 | 90.6 | -1.3 | 69 | 71.3 | -0.5 |
| GGUU | 205 | 201.3 | 0.5 | 175 | 181.2 | -0.8 | 127 | 123.2 | 0.6 | CGUU | 59 | 83.2 | -4.8 | 88 | 104.4 | -2.9 | 53 | 81.6 | -5.8 |
| GUAA | 165 | 174.4 | -1.3 | 135 | 160.2 | -3.6 | 101 | 130.5 | -4.7 | CUAA | 154 | 145.5 | 1.3 | 128 | 140 | -1.8 | 141 | 153.8 | -1.9 |
| GUAC | 99 | 109.2 | -1.8 | 86 | 110.2 | -4.2 | 143 | 109 | 5.9 | CUAC | 112 | 88.1 | 4.6 | 95 | 87.5 | 1.5 | 160 | 140.2 | 3.0 |
| GUAG | 112 | 118.4 | -1.1 | 104 | 136.9 | -5.1 | 96 | 88.6 | 1.4 | CUAG | 78 | 86.6 | -1.7 | 74 | 103.6 | -5.3 | 75 | 99.2 | -4.4 |
| GUAU | 191 | 195.4 | -0.6 | 166 | 172 | -0.8 | 94 | 118.6 | -4.1 | CUAU | 163 | 148.3 | 2.2 | 182 | 150.6 | 4.7 | 177 | 162 | 2.1 |
| GUCA | 85 | 95.2 | -1.9 | 105 | 98.5 | 1.2 | 114 | 113.3 | 0.1 | CUCA | 59 | 75 | -3.4 | 73 | 82.5 | -1.9 | 137 | 130.2 | 1.1 |
| GUCC | 30 | 52.2 | -5.6 | 59 | 73.4 | -3.1 | 35 | 52.7 | -4.4 | CUCC | 33 | 41 | -2.3 | 62 | 58.7 | 0.8 | 46 | 62.3 | -3.7 |
| GUCG | 33 | 39.6 | -1.9 | 35 | 59 | -5.7 | 40 | 51.3 | -2.9 | CUCG | 21 | 32 | -3.5 | 39 | 46 | -1.9 | 43 | 59.9 | -4.0 |
| GUCU | 97 | 109.1 | -2.1 | 125 | 120.1 | 0.8 | 104 | 112.9 | -1.5 | CUCU | 84 | 82 | 0.4 | 110 | 94.8 | 2.8 | 126 | 136.9 | -1.7 |
| GUGA | 122 | 162.3 | -5.8 | 152 | 163.3 | -1.6 | 131 | 127 | 0.6 | CUGA | 107 | 124.3 | -2.8 | 108 | 139.4 | -4.8 | 141 | 150.6 | -1.4 |
| GUGC | 113 | 115.2 | -0.4 | 149 | 148.5 | 0.1 | 130 | 110.9 | 3.3 | CUGC | 109 | 91.9 | 3.2 | 141 | 110.9 | 5.2 | 159 | 128.2 | 4.9 |
| GUGG | 158 | 146.3 | 1.8 | 180 | 158.8 | 3.1 | 109 | 101 | 1.4 | CUGG | 121 | 98.1 | 4.2 | 136 | 123.2 | 2.1 | 106 | 104.8 | 0.2 |
| GUGU | 245 | 218.3 | 3.3 | 269 | 223.8 | 5.5 | 174 | 129.3 | 7.2 | CUGU | 151 | 157.5 | -0.9 | 164 | 179.7 | -2.1 | 152 | 159.3 | -1.1 |
| GUUA | 255 | 244.6 | 1.2 | 237 | 225.1 | 1.4 | 126 | 168.7 | -6.0 | CUUA | 143 | 152.3 | -1.4 | 125 | 150.3 | -3.8 | 164 | 163.1 | 0.1 |
| GUUC | 104 | 123 | -3.1 | 119 | 116.6 | 0.4 | 97 | 114.8 | -3.0 | CUUC | 68 | 80.6 | -2.5 | 76 | 81.3 | -1.1 | 148 | 124.3 | 3.9 |
| GUUG | 280 | 254.7 | 2.9 | 283 | 248 | 4.0 | 165 | 169.1 | -0.6 | CUUG | 168 | 147.9 | 3.0 | 154 | 152.9 | 0.2 | 190 | 154.7 | 5.2 |
| GUUU | 344 | 316.4 | 2.8 | 253 | 239.5 | 1.6 | 192 | 171 | 2.9 | CUUU | 211 | 212.4 | -0.2 | 191 | 177.1 | 1.9 | 209 | 183.8 | 3.4 |