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. 2004 Jul;124(1):59–69. doi: 10.1085/jgp.200308948

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Copyright © 2004, The Rockefeller University Press

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Figure 5. — Effect of NPPB on the CCh-induced Cl⁻ currents. (A) Representative trace showing the effect of 4 μM NPPB on the CCh-induced Cl⁻ current in the conventional whole-cell patch configuration. (B) Representative trace showing the effect of 4 μM NPPB on the CCh-induced anion current recorded under the gramicidin-perforated patch configuration. CCh (500 nM), NPPB (4 μM), and bumetanide (Bum, 500 μM) were added to the perfusate during the period indicated by the horizontal bars. (C) Comparison of NPPB sensitivity of the CCh-induced anion currents under either the conventional whole-cell patch (black columns) or the gramicidin-perforated patch configurations (white columns). The relative currents after the addition of the various concentrations of NPPB were determined from the current traces as shown in A and B. The relative currents are expressed as a percentage of the anion current induced by CCh alone under either the conventional whole-cell patch or the gramicidin-perforated patch configurations (n = 3 or 4).