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. 2004 Aug;124(2):185–197. doi: 10.1085/jgp.200308950

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Copyright © 2004, The Rockefeller University Press

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Figure 5. — The slow component of gating currents is reduced in the hSlo-D292N channel. (A) Gating current traces for hSlo and hSlo-D292N for a pulse from −50 mV to 150 mV. (B) ON gating currents (inset of A) with τ_fast = 0.052 ms and τ_slow = 1.1 ms; the slow component amplitude was reduced from 70% in hSlo to 25% in hSlo-D292N. (C) OFF gating currents (inset of A) with superimposed fits: τ_fast = 0.022 ms, τ_medium = 0.083 ms, τ_slow = 0.350 ms, for both clones; the relative amplitudes of the components were A_fast = 51%, A_medium = 35%, and A_slow = 14% for hSlo, and A_fast = 89%, A_medium = 10%, and A_slow = 1% for hslo D292N. Gating current recordings in 120 mM TEAMES and 1.5 μM free Ca²⁺.