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. 2004 Aug;124(2):185–197. doi: 10.1085/jgp.200308950

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Copyright © 2004, The Rockefeller University Press

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Figure 9. — Variance analysis shows a reduced limiting Po for the mutant hSlo-D292N channels. (A and B) Superimposed K⁺ current traces (100) recorded with pulses from −50 mV to 250 mV in 120 symmetrical K-MES with 1.5 μM free Ca²⁺ from hSlo (A) and hSlo-D292N (B). (C and D) Variance–mean current plots in two other patches for hSlo (C) and hSlo D292N (D). Data points were fitted to σ²(t) = I(t)i − (I(t)²/N), where σ² is the variance, I the mean current, i the single channel current, and N the number of channels. Values were for hSlo PO_max = 0.72, i = 39 pA, and N = 419, and for hSlo-D292N PO_max = 0.26, i = 19 pA, and N = 1,000.