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. 2004 Aug;124(2):173–184. doi: 10.1085/jgp.200308949

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Copyright © 2004, The Rockefeller University Press

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Figure 3. — Drastic reduction of inward currents by the D292N mutation. (A) Current recordings from inside-out patches of oocytes expressing hSlo (left) and hSlo-D292N (right) channels. The voltage protocol is shown above the current traces. Note the lack of detectable single channel tail currents for the mutant channels (right). Linear components were subtracted using traces without channel openings. (B) Macroscopic current recordings from hSlo (left), hSlo-D292N (middle), and uninjected oocyte (right). The current was elicited by the voltage protocol shown above the traces, with a P/4 subtraction protocol from −90 mV subtracting holding potential. Note the smaller tail current amplitude of hSlo-D292N when compared with hSlo.