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. 2004 Aug;124(2):173–184. doi: 10.1085/jgp.200308949

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Copyright © 2004, The Rockefeller University Press

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Figure 7. — A molecular and functional model of the pore region. (A) Simple estimate of the surface charge density in hSlo by considering the area delimited by the circle (25 Å diameter). A surface charge density of ∼0.008 e−/Å² can be estimated for the area including the four negative charges of the D292 residues. This value is very close to the fitted value of 0.0077 e−/Å². (B) Cartoon representation of the proposed role of D292 as a site for accumulating K⁺ ions in the outer vestibule. The selectivity filter is depicted with five K⁺ binding sites. The reduced [K⁺] in the outer vestibule of hSlo-D292N results in reduced accessibility of K⁺ to the outer binding site of the selectivity filter. Inner negative charge residues participating in ion conduction are shown at the bottom of the inner vestibule (Brelidze et al., 2003; Nimigean et al., 2003).