Table 2.
(A) Blood pressure parameters measured under basal conditions in adult offspring of VEH- and dexamethasone (DEX)-treated dams. (B) Table of P values resulting from MANOVA of telemetry data in A. Dependent variables are prenatal treatment (VEH or DEX), gender and day or night measurements. Results are mean±s.d. (number of observations), from all data collected over 72-h period for each rat
| (A) Telemetry data | ||||
|---|---|---|---|---|
| VEH ♂ | DEX ♂ | VEH ♀ | DEX ♀ | |
| Systolic (mmHg) | ||||
| Av daily BP | 144·5±10·6 (750) | 140·2±15·2 (717) | 138·3±10·4 (450) | 129·7±12·7 (749) |
| Av BP in light phase | 141·7±9·5 (390) | 138·3±16·2 (386) | 135·2±10·2 (234) | 126·6±11·8 (390) |
| Av BP in dark phase | 147·6±11·0 (360) | 142·5±13·7 (331) | 141·6±9·5 (216) | 133·1±12·8 (359) |
| Diastolic (mmHg) | ||||
| Av daily BP | 106·1±9·8 (750) | 103·3±12·8 (717) | 101·5±8·9 (450) | 99·4±13·0 (749) |
| Av BP in light phase | 103·4±8·6 (390) | 101·6±13·4 (386) | 99·4±8·4 (234) | 96·3±12·0 (390) |
| Av BP in dark phase | 109·0±10·2 (360) | 105·3±11·4 (331) | 103·8±8·9 (216) | 102·7±13·3 (360) |
| MAP (mmHg) | ||||
| Av daily BP | 118·9±10·6 (750) | 115·6±15·5 (717) | 113·8±9·2 (450) | 109·4±4·7 (749) |
| Av BP in light phase | 116·1±8·7 (390) | 113·9±14·4 (386) | 111·3±8·9 (234) | 106·4±11·7 (390) |
| Av BP in dark phase | 121·9±10·3 (360) | 117·7±12·1 (331) | 116·4±8·9 (216) | 112·7±12·9 (359) |
| Pulse pressure (mmHg) | ||||
| Av daily PP | 38·5±3·9 (750) | 36·9±3·7 (717) | 36·8±4·0 (450) | 30·4±5·9 (749) |
| Av PP in light phase | 38·3±3·7 (390) | 36·7±3·8 (386) | 35·8±3·8 (234) | 30·3±5·1 (390) |
| Av PP in dark phase | 38·7±4·2 (360) | 37·2±3·6 (331) | 37·8±4·08 (216) | 30·4±5·9 (359) |
| Heart Rate (beats/min) | ||||
| Av daily HR | 339·3±60·4 (750) | 349·2±62·3 (717) | 366·9±64·2 (450) | 366·0±62·2 (750) |
| Av HR in light phase | 306·7±44·1 (390) | 323·1±53·3 (386) | 335·7±54·8 (234) | 332·1±48·4 (390) |
| Av HR in dark phase | 374·6±55·7 (360) | 379·6±58·4 (331) | 400·7±56·0 (216) | 398·7±56·5 (359) |
| Activity (arbitrary units) | ||||
| Av daily activity | 2·88±2·81 (745) | 2·51±2·50 (745) | 4·85±4·38 (447) | 3·50±3·74 (750) |
| Av activity in light phase | 1·41±1·73 (385) | 1·29±1·58 (385) | 2·53±2·90 (231) | 1·70±2·25 (385) |
| Av activity in dark phase | 4·46±2·88 (360) | 3·82±2·64 (360) | 7·32±4·34 (216) | 5·42±4·05 (360) |
| (B) P values resulting from MANOVA of telemetry data | |||||
|---|---|---|---|---|---|
| PNT | Day/night | Gender | Interaction PNT×gender | Interaction PNT×day/night phase | |
| Parameter | |||||
| SBP | 0·001 | 0·001 | 0·001 | 0·003 | 0·467 |
| DBP | 0·001 | 0·001 | 0·001 | 0·008 | 0·847 |
| MAP | 0·001 | 0·001 | 0·001 | 0·489 | 0·894 |
| PP | 0·001 | 0·001 | 0·001 | 0·001 | 0·017 |
| HR | 0·038 | 0·001 | 0·001 | 0·002 | 0·236 |
| Activity | 0·001 | 0·001 | 0·001 | 0·001 | 0·001 |
Bold numbers indicate significance (P<0·05) of dependent variables and interactions of these variables. SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure; HR, heart rate.