Table 1. Summary of Baseline characteristics by treatment group.
SP | CQ+SP | ART+SP | AQ+SP | |
Number of patients | 114 | 113 | 114 | 114 |
Median age (months), (IQR) | 22.6 (17.6) | 22.2 (14.0) | 21.6 (8.2) | 21.0 (14.2) |
Number (%) female | 62 (54.4%) | 54 (47.8%) | 51 (44.7%) | 56 (49.1%) |
Number of days of fever | 3.1 (1.8) | 2.9 (1.8) | 3.1 (1.9) | 3.1 (1.7) |
Weight (kg) | 10.9 (2.2) | 10.8 (2.3) | 10.8 (2.1) | 10.8 (2.4) |
Initial temperature (°C) | 38.8 (0.9) | 38.7 (0.9) | 38.8 (0.9) | 38.8 (0.9) |
Geometric mean (range) parasite count* (per µl) | 66,171 (973–301,294) | 59,874 (2146–280,720) | 36,315 (1077–306,722) | 44,356 (1892–288,353) |
Parasite count>200,000/µl (%) | 10 (8.8%) | 16 (14.2%) | 9 (7.9%) | 13 (11.4%) |
Gametocytes seen on Day 0 | 18 (15.8%) | 15 (13.3%) | 18 (15.8%) | 19 (16.7%) |
Haemoglobin** (g/dl) | 9.1 (1.7) | 9.0 (1.6) | 8.9 (1.4) | 9.3 (1.6) |
White cell count (x109/L) | 10.2 (4.3) | 10.8 (4.6) | 9.9 (4.4) | 10.3 (4.7) |
Neutrophil count (x109/L) | 5.1 (3.6) | 5.2 (3.6) | 4.1 (2.9) | 5.3 (4.1) |
Platelet count (x109/L) | 149 (91) | 165 (93) | 163 (100) | 162 (103) |
Alanine Transferase (IU/L) | 19 (13) | 18 (17) | 18 (16) | 22 (19) |
Total Bilirubin (mg/dl) | 0.97 (0.5) | 0.95 (0.7) | 0.88 (0.7) | 0.85 (0.6) |
Creatinine (mg/dl) | 0.4 (0.1) | 0.4 (0.1) | 0.4 (0.1) | 0.4 (0.1) |
For all, data shows mean (SD) unless otherwise indicated
Parasite count calculated using coulter HB and WCC
HB from coulter counter. If not available, the Hemocue HB was used (n = 5)