Table 3.
Demographic and virologic characteristics of hepatitis B virus chronic carriers and patients with hepatocellular carcinoma
| Chronic carriers | Patients with HCC | |||
|---|---|---|---|---|
| Characteristics* | n = 67 | n = 101 | P value | OR (95% CI)† |
| Age | 45.4 ± 12.3 SD years | 53.3 ± 13.5 SD years | 0.002 | 1.05 (1.02–1.08) |
| Gender | ||||
| Female | 38 (56.7%) | 17 (17.0%) | 0.0001 | 1 |
| Male | 29 (43.3%) | 84 (83.0%) | 6.47 (3.18–13.18) | |
| Asian | ||||
| No | 9 (13.4%) | 9 (8.9%) | 0.35 | 1 |
| Yes | 58 (86.6%) | 92 (91.1%) | 1.59 (0.59–4.23) | |
| HBV genotype C | ||||
| No | 27 (65.8%) | 30 (31.9%) | 0.0003 | 1 |
| Yes | 14 (34.2%) | 64 (68.1%) | 4.11 (1.89–8.95) | |
| PC | ||||
| Wild type | 44 (69.8%) | 54 (54.0%) | 0.04 | 1 |
| A1896 mutant | 19 (30.2%) | 46 (46.0%) | 1.97 (1.01–3.84) | |
| BCP | ||||
| Wild type | 37 (78.7%) | 21 (22.3%) | 0.0001 | 1 |
| T1762/A1764 mutant | 10 (21.2%) | 73 (77.7%) | 12.86 (5.49–30.11) | |
| HBV load | ||||
| ≤105 copies/mL | 67 (100.0%) | 63 (51.5%) | 0.0001 | NA |
| >105 copies/mL | 0 (0.0%) | 38 (48.5%) | ||
*
Data are provided as n (%) or mean ± SD.
†
When n (%) is provided, the P value and OR (95% CI) is reported from χ2 tests or Fisher's exact test. In case of mean ± SD, the P value is reported from t-tests and OR (95% CI) is reported from univariate logistic regression.
BCP, basal core promoter; CI, confidence interval; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; NA, not applicable; OR, odds ratio; PC, precore; SD, standard deviation.