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. 1999 Nov 1;114(5):701–711. doi: 10.1085/jgp.114.5.701

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The effect of regulatory Ca²⁺ _i on recovery of NCX1.4 and NCX1.3 from Na⁺ _i-dependent inactivation using paired-pulse stimulation. The indicated concentrations of regulatory Ca²⁺ _i were present throughout the current measurements. The first pulse was activated by applying 100 mM Na⁺ _i for 32 s, followed by a 4-s recovery interval. A second, test pulse was then elicited by reapplication of 100 mM Na⁺ _i. The graph (bottom) shows representative results from four patches each of NCX1.4 and NCX1.3 over a range of regulatory [Ca²⁺]_i.