Table 4.
Genetic interactions among export factors
| A. Synthetic effects between export factors |
|
|---|---|
| nmd3(AAA) X arx1Δ | SL |
| nmd3-1 X mex67-5 | SL |
| nmd3(AAA) X mtr2-33 | SL |
| arx1Δ X mex67-5 | SS |
| arx1Δ X mtr2-33 | SL |
| B. High copy expression of export factors | |||||
|---|---|---|---|---|---|
| Mutant |
High copy expression |
||||
|
NMD3 |
ARX1 |
MEX67 |
MTR2 |
CRM1 |
|
| nmd3(AAA) | SUP | SUP | DN | DN | |
| arx1Δ | DN | SUP | SUP | DN | |
| mex67-5 | No effect | No effect | SUP | DN | |
| mtr2-33 | DN | No effect | No effect | DN | |
SL, Synthetic lethal; SS, Synthetic sickness; SUP, suppression; DN, dominant negative.