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Down-regulation of human SOSTDC1 mRNA in kidney tumors. cDNA of matched normal and tumor kidney tissue from the same patient was hybridized with radiolabeled DNA oligonucleotides to human SOSTDC1. N, normal (lane 1); T, tumor (lane 2). SOSTDC1 cDNA decreases in normal versus tumor tissue in 20 of 20 patients; 14 of 20 (70%) of tumors show virtually no detectable SOSTDC1 mRNA.
