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. 2008 Feb;19(2):457–464. doi: 10.1091/mbc.E07-05-0433

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© 2008 by The American Society for Cell Biology

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Figure 4. — Normal human SOSTDC1 is secreted and binds to matrix or cell surface proteins around neighboring cells. HEK293 cells were transfected with SOSTDC1-FLAG, and expression was analyzed using rhodamine-conjugated anti-FLAG antibody (mouse anti-FLAG-rh). Nuclei were stained with DAPI. (A–C) Color fluorescent image. (D–F) Corresponding black and white channel of same images. All images were obtained at the same magnification and exposure. (A and D) A highly expressing cell (arrow) shows strong signal in the cytoplasm, especially the endoplasmic reticulum and Golgi apparatus. (B and E) Secreted SOSTDC1 (small arrowheads) accumulates around both expressing and nonexpressing cells. (C and F) Empty vector control transfected cells show no background rhodamine fluorescence. N, nucleus.