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. 2000 Oct 1;116(4):587–598. doi: 10.1085/jgp.116.4.587

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Schematic diagram of the whole colicin Ia molecule in the open channel state in a planar bilayer. Helices 1–10 of the carboxy-terminal C domain are labeled to show their topology in the membrane, with four membrane-spanning segments (helices 8 and 9 and portions of helices 1 and 6–7) and a translocated segment (helices 2–5). The C domain begins at about residue 451, in helix 1, which is located near the cis interface. The amino-terminal T domain and the central R domain, as well as the two long inter-domain helices, are presumed to reside on the cis side of the membrane.