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. 1999 Aug 1;114(2):251–270. doi: 10.1085/jgp.114.2.251

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Plot of the reciprocal of the corrected mean open time (t_o) against [ATP] before (•) and after treatment with PPIs (5 min, 1 mg/ml) (○). (A) Data from rat ventricular myocytes (Table ). The lines are fits to with inhibition rate constants of 0.8 and 0.02 mM⁻¹ ms⁻¹ for K _is of 35 μM and 5.8 mM for control and after treatment with PPIs, respectively. (B) Data for Kir6.2ΔC35 channels expressed in COS-1 cells converted from Table . The lines are obtained by taking an inhibition rate constant of 0.6 and 0.3 mM⁻¹ ms⁻¹ for K _is of 247 μM and 2.1 mM for control and after treatment with PPIs, respectively.