Figure 1.

Effects of EUK-134 treatment on KA-induced changes in nitrotyrosine immunoreactivity. Rats were treated with KA or KA & EUK as described in Materials and Methods. They were killed 8 h after treatment and perfused with paraformaldehyde. Coronal brain sections (8 μm thick) were processed for immunohistochemistry with an antibody specific for nitrotyrosinated proteins. Note the large increase in immunoreactivity in pyramidal cell bodies of CA1 and CA3 in the KA group (arrows) and the complete blockade of the effect in the KA & EUK group.