Figure 4.

Effects of EUK-134 treatment on KA-induced neuronal damage. Control and KA-treated rats were killed 5 days after KA injection. Frozen brain sections were stained with H&E and examined by light microscopy. Damaged neurons were identified as those exhibiting eosinophilic cytoplasm and condensed nuclei. For each rat, the percentage of damaged neurons was determined in two separate sections (all pyramidal cells in CA1 and CA3 or 500 cells in piriform cortex were counted, respectively) and the values were averaged. Results represent the means ± SD of data from six rats in each group. Statistically significant differences between KA and KA & EUK groups are indicated by ∗.