Figure 1. The VDCC oligomeric complex.

Binding sites on the α1 I-II loop for VDCC β and Gβγ are shown. All VDCC α1 subunits have a binding site for β (α interaction domain, AID) on this loop, but Gβγ binding has only been shown for α1A, α1B and α1E. Regions of the C-terminal tail of human α1E which may be involved in VDCC β and Gβγ binding are also indicated. BID, β interaction domain.