Each panel shows original recordings of changes in fluorescence (excitation wavelengths, 340 nm (F340) and 380 nm (F380)) of the intracellular [Ca2+]i-sensitive dye fura-2 (upper records), calculated [Ca2+]i (middle records), and perfusion pressure at constant flow rate (bottom records) following intraluminal perfusion of noradrenaline (S1-S6, 3 μM, 2 min).