Figure 2. Current-voltage relationships for I_t (A) and for the steady-state current magnitudes (B), obtained by measurements at the end of 500 ms pulses.

I_ss is represented by values between -30 and +50 mV, and I_K1 by values between -40 and -110 mV. C, summary data showing the current densities (pA pF⁻¹) at +50 mV, measured in myocytes from control rats (n = 34 myocytes), STZ-treated rats (n = 31) and fructose-fed rats (n = 30). I_t (left) decreased significantly only in the STZ model. I_ss (right) decreased in the STZ model but increased in the fructose model. I_K1 was not significantly altered, as can be seen in the current-voltage relationships in B. Values are means ± s.e.m.; *P < 0.05, compared with control.