Figure 8. Effect of the calcium entry blocker SKF 96365 on the permeability response to dimaprit of a single vessel.

When SKF 96365 (10 μm) was applied shortly after dimaprit (5 μm) to an occluded microvessel (diameter, 14 μm), the rate of dye loss was promptly reduced (A). However, when dimaprit was applied to a vessel in the presence of SKF 96365, there was a transient increase in rate of dye loss which lasted for about 20 s (B). The P_LY values are given below the relevant parts of the curves (expressed as 10⁻⁶ cm s⁻¹).