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. 1998 Apr 1;508(Pt 1):119–129. doi: 10.1111/j.1469-7793.1998.119br.x

Figure 4. Effects of serotonin on AMPAR- and NMDAR-mediated EPSCs.

Figure 4

Serotonin depressed both AMPAR-mediated (in APV, bicuculline and CGP 55845A) and NMDAR-mediated (in NBQX, bicuculline and CGP 55845A) EPSCs in 2 different cells, when measured with a patch electrode, where the intracellular milieu was changed by perfusion with the internal solution of the patch pipette. A, 5-HT reduced the AMPAR-mediated EPSCs in a layer II neuron of the entorhinal cortex, while the kinetics of the event were unchanged (right). There was no detectable slow outward current following the application of 5-HT. B, 5-HT also reduced the NMDAR-mediated EPSCs in another cell of the superficial layers of the entorhinal cortex, while the kinetics of the event were again unchanged (right).